Metastasis: Lung Parenchyma Lesion

Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site. Change metastases list to be ungrouped by characteristic.

Cavitary

Cancer	Frequency	Comments
Non-Small Cell Lung Carcinoma	(Primary Tumor)	BAC presents as a single or multiple consolidations (in early stages, it appears as a ground-glass opacity). SCC is more likely to cavitate.
Squamous Cell Carcinoma of the Head and Neck	Common	by far, the most common site of metastasis
Cervical Cancer	Uncommon	SCC lung metastases can cavitate

Central

Cancer	Frequency	Comments
Small Cell Lung Cancer	(Primary Tumor)	the mass is typically central and may invade the mediastinum

Consolidation

Cancer	Frequency	Comments
Non-Small Cell Lung Carcinoma	(Primary Tumor)	BAC presents as a single or multiple consolidations (in early stages, it appears as a ground-glass opacity). SCC is more likely to cavitate.
Non-Small Cell Lung Carcinoma	Uncommon	bronchoalveolar metastases appear as consolidation, while classical lung cancers will just appear as nodules (or lymphangiitic spread)
Non-Hodgkin's Lymphoma	Rare
Hodgkin's Lymphoma	Rare	can also invade locally from the hilum or mediastinum. Most common pattern is nodules.

Lymphangiitic

Cancer	Frequency	Comments
Non-Small Cell Lung Carcinoma	Uncommon	bronchoalveolar metastases appear as consolidation, while classical lung cancers will just appear as nodules (or lymphangiitic spread)
Hodgkin's Lymphoma	Rare	can also invade locally from the hilum or mediastinum. Most common pattern is nodules.

Nodule

Cancer	Frequency	Comments
Colorectal Adenocarcinoma	Common
Wilms Tumor	Common	most common metastatic site
Non-Small Cell Lung Carcinoma	Uncommon	bronchoalveolar metastases appear as consolidation, while classical lung cancers will just appear as nodules (or lymphangiitic spread)
Renal Cell Carcinoma	Common	most common site
Prostate Adenocarcinoma	Rare
Melanoma	Common	second most-common site
Endometrial Cancer	Common
Testicular Cancer	Common
Hepatocellular Carcinoma	Common	most common distant site
Esophageal Cancer	Common	most common site for distant metastases from SCC (second most common for adeno)
Merkel Cell Carcinoma	Common
Small Cell Lung Cancer	Rare	contralateral lung
Papillary Thyroid Carcinoma	Common	most common site for first distant metastasis
Medullary Thyroid Carcinoma	Common
Adrenal Cortical Carcinoma	Common
Cervical Cancer	Uncommon	SCC lung metastases can cavitate
Epithelial Ovarian Cancer	Uncommon
Osteosarcoma	Common	by far the most common site. sarcoma metastases can cause pneumothorax
Basal Cell Carcinoma	Common
Mixed Mullerian Tumor of the Uterus	Common	Most common metastatic site. Also, uterine carcinosarcoma has the highest rate of pulmonary metastases among uterine malignancies
Pancreatic Adenocarcinoma	Uncommon
Gastric Adenocarcinoma	Rare
Rhabdomyosarcoma	Common	Most common site of metastasis, with best prognosis
Transitional Cell Carcinoma of the Bladder	Common
Gallbladder Cancer	Uncommon
Gastrointestinal Carcinoid	Uncommon
Cholangiocarcinoma	Rare
Neuroblastoma	Rare
Non-Hodgkin's Lymphoma	Rare
Hemangiopericytoma	Common
Pancreatic Neuroendocrine	Very Rare
Gastrointestinal Stromal Tumor	Very Rare
Medulloblastoma	Uncommon	more common in adults
Astrocytoma	Common	most common site of extracranial metastasis
Hodgkin's Lymphoma	Rare	can also invade locally from the hilum or mediastinum. Most common pattern is nodules.
Dermatofibrosarcoma Protuberans	Common
Pheochromocytoma	Uncommon

Ossified

Cancer	Frequency	Comments
Osteosarcoma	Common	by far the most common site. sarcoma metastases can cause pneumothorax

Pneumothorax

Cancer	Frequency	Comments
Osteosarcoma	Common	by far the most common site. sarcoma metastases can cause pneumothorax

Spiculated

Cancer	Frequency	Comments
Non-Small Cell Lung Carcinoma	(Primary Tumor)	BAC presents as a single or multiple consolidations (in early stages, it appears as a ground-glass opacity). SCC is more likely to cavitate.