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Metastatic Pattern of Spread of Renal Cell Carcinoma  adult

Introduction: Cancer arising from the kidney parenchyma. The most common histologic type is clear cell; less common types include papillary and chromophobe.

Prevalence: Uncommon Metastasis Frequency: Common

"Distribution of metastatic sites in renal cell carcinoma: a population-based analysis." Ann Oncol. 2011 Sep 2. PMID: 21890909

AJR Am J Roentgenol. 2001 Sep;177(3):653-8. PMID: 11517065

Primary Tumor:

 Characteristics Comments
Kidney Solid, Cystic, Hyperenhancing Appearance can vary widely. (see Radiographics. 2006 Nov-Dec;26(6):1795-806 PMID: 17102051)

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Lung Parenchyma CommonNodule most common site
Bone CommonLytic
Local Lymph Nodes Common
Surrounding Tissue Common nephrectomy fossa
Renal Vein Common
Distant Lymph Nodes Uncommon
Liver UncommonHyperenhancing, Arterially Enhancing
Adrenal Glands Rare
Brain Rare
Retroperitoneum Rare
Pleura Very Rare
Bladder Very Rare
Mediastinum Very Rare
Kidney Very Rare (as a metastasis)
Colon Very Rare
Small Intestine Very Rare
Ovary Very Rare
Pancreas Very RareHyperenhancing
radiology image: Pancreatic metastasis
Bronchus Very Rare PMID: 16475029 PMID: 11259704 PMID: 11243955
Muscle Very Rare especially erector spinae
Gallbladder Very Rare
radiology image: Gallbladder metastasis