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Metastasis: Lytic Bone Lesion

Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site.


Non-Small Cell Lung Carcinoma Common adult
Renal Cell Carcinoma Common adult
Hepatocellular Carcinoma Common adult
Melanoma Uncommon adult
Medullary Thyroid Carcinoma Common adult predominantly lytic. mixed and blastic lesions have been described, however.
Neuroblastoma Common child Metastatic involvement of the skull has been found in up to 25% of patients with neuroblastoma. Neuroblastoma is the most common malignant metastasis to the skull in children. AJR Am J Roentgenol. 2010 May;194(5):1223-9. PMID: 20410407
Esophageal Cancer Uncommon adult
Basal Cell Carcinoma Common adult
Squamous Cell Carcinoma of the Head and Neck Uncommon adult
Papillary Thyroid Carcinoma Uncommon adult second most common site for first distant metastasis
Cervical Cancer Rare adult
Endometrial Cancer Rare adult
Testicular Cancer Rare adultchild involvement occurs late
Gastrointestinal Stromal Tumor Rare adult
Gastrointestinal Carcinoid Uncommon adult Classically, these are blastic metastases, but a recent series showed both lytic and blastic lesions (PMID: 12571207).
Epithelial Ovarian Cancer Very Rare adult
Gallbladder Cancer Rare adult
Hemangiopericytoma Common adult
Astrocytoma Common adult
Cholangiocarcinoma Very Rare adult
Hodgkin's Lymphoma Rare adultchild Most commonly involves the spine. Involves bone usually by direct extension.
Non-Hodgkin's Lymphoma Very Rare adultchild