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Metastatic Pattern of Spread of Cholangiocarcinoma  adult

Introduction: Cholangiocarcinoma is cancer arising from the intrahepatic or extrahepatic bile ducts, almost exclusively adenocarcinoma. Cancer at the convergence of the right and left bile ducts is termed a Klatskin tumor.

Prevalence: Very Rare Metastasis Frequency: Common

Surgery. 2002 Jan;131(1 Suppl):S159-64. PMID: 11821804

Hum Pathol. 1988 Oct;19(10):1228-34. PMID: 2844646

Radiographics. 2008 Sep-Oct;28(5):1263-87. PMID: 18794305

Arch Pathol Lab Med. 2008 Jun;132(6):931-9. PMID: 18517275

Primary Tumor:

 Characteristics Comments
Bile Duct Obstructing various patterns of bile duct involvement are described

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Liver CommonBiliary Duct Dilatation, Satellite, Delayed Enhancement the tumor spreads along bile ducts and vascular channels
radiology image: Satellite Lesions radiology image: Biliary Ductal Dilatation
Local Lymph Nodes Common
Distant Lymph Nodes Common intra-abdominal but beyond the local nodes
Peritoneum Common
radiology image: Peritoneal Carcinomatosis radiology image: Peritoneal Carcinomatosis and Laparoscopy Tract Seeding
Adrenal Glands Rare
Lung Parenchyma RareNodule
Bone Very RareLytic
Gallbladder Very Rare
Colon Very Rare
Pancreas Very Rare
Pleura Very Rare
Spleen Very Rare