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Metastatic Pattern of Spread of Papillary Thyroid Carcinoma  adult

Introduction: Most common type of thyroid cancer. Metastases outside of local lymph nodes are rare. (Mets to local lymph nodes are very common.)

Prevalence: Uncommon Metastasis Frequency: Rare

J Clin Endocrinol Metab. 1995 Jul;80(7):2041-5. PMID: 7608252

Endocr Relat Cancer. 2011 Aug 30;18(5):R165-74. doi: 10.1530/ERC-11-0068. PMID: 21632805

Primary Tumor:

 Characteristics Comments
Thyroid Microcalcified

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Lung Parenchyma CommonNodule most common site for first distant metastasis
Local Lymph Nodes Common much more common than distant metastases
Bone UncommonLytic second most common site for first distant metastasis
Mediastinum Uncommon
Brain Rare rare as a first site for distant metastasis but the most common site for second distant metastasis
Adrenal Glands Very Rare
Skin (Cutaneous and Subcutaneous) Very Rare
Liver Very Rare