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Metastatic Pattern of Spread of Gastrointestinal Stromal Tumor  adult

Introduction: Also known by its acronym, GIST, it is a rare tumor arising from the interstitial cells of Cajal (pacemaker cells) within the GI tract.

Prevalence: Very Rare Metastasis Frequency: Common

Radiology. 2003 Feb;226(2):527-32. PMID: 12563150

"Unusual metastatic sites in gastrointestinal stromal tumor (GIST)" J Clin Oncol 27:15s, 2009 (suppl; abstr 10566)

"Incidence of bone metastases in GIST: A single center analysis of 307 patients with metastatic disease." J Clin Oncol 26: 2008 (May 20 suppl; abstr 10565)

Primary Tumor:

 Characteristics Comments
Small Intestine Intramural, Centrally Necrotic, Large, Calcified most common sites are stomach and small intestine (about equally)

often endophytic and/or exophytic components

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Liver CommonHypoenhancing
Peritoneum Common
Local Lymph Nodes Rare
Bone RareLytic
Retroperitoneum Very Rare
Lung Parenchyma Very RareNodule