Welcome, guest.
Login to edit.


Metastatic Pattern of Spread of Neuroblastoma  child

Introduction: Tumor seen exclusively in childhood, which arise from sympathetic ganglion cells, most commonly in the adrenal gland.

Prevalence: Very Rare Metastasis Frequency: Common

"Do sites of metastases in neuroblastoma correlate with biology?"

J Pediatr Hematol Oncol. 1999 May-Jun;21(3):181-9. PMID: 10363850

AJR Am J Roentgenol. 2010 May;194(5):1223-9. PMID: 20410407

Poachedly, Carl. Neuroblastoma: Tumor Biology and Therapy

Magn Reson Imaging Clin N Am. 2002 May;10(2):275-302. PMID: 12424947

Primary Tumor:

Sorry, no description has been written for the primary tumor.

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Bone Marrow Common most common site of metastatic disease and important prognostic factor
Bone CommonPermeative, Lytic, Periosteal Reaction Metastatic involvement of the skull has been found in up to 25% of patients with neuroblastoma. Neuroblastoma is the most common malignant metastasis to the skull in children. AJR Am J Roentgenol. 2010 May;194(5):1223-9. PMID: 20410407
Local Lymph Nodes Common
Liver CommonHepatomegaly liver metastases are rare in traditional neuroblastoma, but hepatomegaly is a characteristic of "4S" disease - patient < 1 year, skin lesions ("blueberry baby"), and hepatomegaly
Orbit Uncommon See also Bone metastases. Tumor infiltration of the periorbital bones, typically unilateral, can cause the characteristic periorbital ecchymosis ("raccoon eyes"), ptosis, and proptosis. Seen in 15% of patients.
Lung Parenchyma RareNodule
Dura (Meninges) Very Rare
Brain Very RareHemorrhagic
Skin (Cutaneous and Subcutaneous) Very Rare
Testes Very Rare