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Metastasis: Periosteal Reaction Bone Lesion

Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site.


Neuroblastoma Common child Metastatic involvement of the skull has been found in up to 25% of patients with neuroblastoma. Neuroblastoma is the most common malignant metastasis to the skull in children. AJR Am J Roentgenol. 2010 May;194(5):1223-9. PMID: 20410407