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Metastatic Pattern of Spread of Rhabdomyosarcoma  child

Introduction: Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. It exists in alveolar and non-alveolar subtypes. Prognosis is negatively impacted by bone or bone marrow involvement. Lung metastases have a better prognosis than metastases at other sites.

Prevalence: Rare Metastasis Frequency: Uncommon

J Clin Oncol. 2008 May 10;26(14):2384-9. PMID: 18467730

Oncologist. 1999;4(1):34-44. PMID: 10337369

Primary Tumor:

 Characteristics Comments
Genitourinary Botyroid Genitourinary sites most common (bladder, vagina, prostate). The description botyroid is used for the subset that have a 'bunch of grapes' appearance.

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Liver Unspecified Uncommon site of metastasis, frequency unspecified
Lung Parenchyma CommonNodule Most common site of metastasis, with best prognosis
Bone Marrow Common
Bone Common
Distant Lymph Nodes Common