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Metastatic Pattern of Spread of Merkel Cell Carcinoma  adult

Introduction: A very rare skin cancer from neuroendocrine origin. It is related to sun exposure. Both local and distant recurrences are common. However, despite the frequent metastases, CT findings of possible distant metastatic spread have a low specificity (i.e. mostly false positive).

Prevalence: Very Rare Metastasis Frequency: Common

Ann Surg Oncol. 2001 Apr;8(3):204-8. PMID: 11314935

Arch Dermatol. 2006 Jun;142(6):685-90. PMID: 16785370

Primary Tumor:

Sorry, no description has been written for the primary tumor.

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Surrounding Tissue Common
Distant Lymph Nodes Common
Skin (Cutaneous and Subcutaneous) Common
radiology image: Lymphadenopathy and Subcutaneous Nodules
Lung Parenchyma CommonNodule
Local Lymph Nodes Common CT sensitivity for local lymph node involvement is only 20%.
Brain Uncommon
radiology image: Cerebellar Metastasis
Bone Uncommon