Metastasis: Liver Lesion
Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site. Group metastases by characteristic.
| Cancer | Frequency | Comments |
| Colorectal Adenocarcinoma | Common |  most common site |
| Breast Adenocarcinoma | Common | slightly more common in HER2-positive cancers |
| Non-Small Cell Lung Carcinoma | Common | |
| Hepatocellular Carcinoma | (Primary Tumor) | HCC lesions are arterially enhancing (versus normal liver or regenerating nodules, which enhance with the portal venous phase). The display wash-out, i.e. decreased enhancement compared to liver on PV phase. |
| Small Cell Lung Cancer | Common | |
| Wilms Tumor | Uncommon |  |
| Rhabdomyosarcoma | Unspecified | Uncommon site of metastasis, frequency unspecified |
| Pancreatic Adenocarcinoma | Common | |
| Prostate Adenocarcinoma | Rare | |
| Melanoma | Common | |
| Renal Cell Carcinoma | Uncommon | |
| Endometrial Cancer | Common | |
| Testicular Cancer | Common | |
| Hepatocellular Carcinoma | Common | |
| Esophageal Cancer | Common | most common site for distant metastases of adenocarcinoma (second most common for SCC) |
| Gastric Adenocarcinoma | Uncommon | |
| Pancreatic Neuroendocrine | Common | overall, a very common site for metastasis (seen in about half of all pancreatic neuroendocrine tumors). However it is almost never seen from insulinomas and uncommon in VIPoma and gastrinoma. |
| Medullary Thyroid Carcinoma | Common | |
| Adrenal Cortical Carcinoma | Common | |
| Gastrointestinal Stromal Tumor | Common | |
| Cervical Cancer | Uncommon | |
| Epithelial Ovarian Cancer | Uncommon | i.e. parenchymal metastases. hepatic capsular metastases (from peritoneal involvement) are much more common |
| Cholangiocarcinoma | Common | the tumor spreads along bile ducts and vascular channels |
| Gallbladder Cancer | Common | most common site of hematogenous metastasis |
| Neuroblastoma | Common | liver metastases are rare in traditional neuroblastoma, but hepatomegaly is a characteristic of "4S" disease - patient < 1 year, skin lesions ("blueberry baby"), and hepatomegaly |
| Basal Cell Carcinoma | Common | |
| Gastrointestinal Carcinoid | Common | most common distant site. Metastases will be hyperenhancing in the arterial phase, although they may become isointense to liver on later phases. |
| Transitional Cell Carcinoma of the Bladder | Common | |
| Squamous Cell Carcinoma of the Head and Neck | Rare | |
| Osteosarcoma | Rare | |
| Hodgkin's Lymphoma | Uncommon | Never occurs without splenic involvement first. Imaging is unreliable (hepatomegaly does not imply involvement). |
| Non-Hodgkin's Lymphoma | Rare | |
| Pheochromocytoma | Common | |
| Thymoma | Rare | |
| Papillary Thyroid Carcinoma | Very Rare | |
| Medulloblastoma | Uncommon | more common in children |
| Astrocytoma | Common | |