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Metastatic Pattern of Spread of Breast Adenocarcinoma  adult

Introduction: The metastatic site preference does depend on the subtype of the breast cancer and molecular markers.

Prevalence: Common Metastasis Frequency: Common

J Clin Oncol. 2010 Jul 10;28(20):3271-7 PMID: 20498394

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Br J Radiol. 2007 Apr;80(952):284-92. PMID: 17038411

Primary Tumor:

Sorry, no description has been written for the primary tumor.

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Bone CommonMixed Lytic and Blastic less common with triple-negative cancers
radiology image: Mixed Lytic and Sclerotic Metastases
Liver Common slightly more common in HER2-positive cancers
radiology image: Pseudocirrhosis
Local Lymph Nodes Common axillary, subpectoral, supraclavicular, internal mammary
Brain Uncommon more common in HER2-positive and/or ER/PR-positive cancers
Distant Lymph Nodes Uncommon more common in triple-negative cancers
Peritoneum Uncommon
Pleura Uncommon
Stomach UncommonLinitis Plastica
radiology image: Linitis Plastica
Bronchus Very Rare PMID: 16475029 PMID: 11259704 PMID: 11243955
Breast Very RareContralateral most common origin of a metastatic lesion in the breast

Cancer. 2001 Nov 1;92(9):2259-66. PMID: 11745279