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Metastatic Pattern of Spread of Thymoma  adult

Introduction: Thymoma is an uncommon cancer arising from thymic tissue in older adults (40s-50s). It is associated with paraneoplastic syndromes, although the majority of patients are asymptomatic: pure red cell aplasia, hypogammaglobulinemia, and myasthenia gravis.

Prevalence: Rare Metastasis Frequency: Rare

J Clin Oncol. 1999 Jul;17(7):2280-9. PMID: 10561285

Radiographics. 2002 Oct;22 Spec No:S95-S102. PMID: 12376603

Primary Tumor:

 Characteristics Comments
Mediastinum Peripherally Calcified anterior mediastinum. often contains calcifications

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Pleura Common so-called 'drop' metastases (i.e. local seeding of the pleura)
Kidney Rare
Bone Rare
Liver Rare
Brain Rare