Metastasis: Local Lymph Nodes Lesion
Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site. Group metastases by characteristic.
| Cancer | Frequency | Comments |
| Colorectal Adenocarcinoma | Common |  colon: typically along the inferior mesenteric artery
rectal: typically retroperitoneal (esp internal iliac) |
| Prostate Adenocarcinoma | Common | typically obturator, internal iliac, common iliac, and presacral chains |
| Breast Adenocarcinoma | Common | axillary, subpectoral, supraclavicular, internal mammary |
| Wilms Tumor | Common |  |
| Small Cell Lung Cancer | Common | hilar and mediastinal |
| Renal Cell Carcinoma | Common | |
| Gastric Adenocarcinoma | Common | |
| Cervical Cancer | Common | retroperitoneal and para-aortic |
| Endometrial Cancer | Common | iliac / para-aortic |
| Testicular Cancer | Common | para-aortic chains |
| Epithelial Ovarian Cancer | Common | para-aortic |
| Hepatocellular Carcinoma | Common | regional lymph nodes - perihepatic, peripancreatic, and retroperitoneal - found in 30-40% of cases |
| Esophageal Cancer | Common | mediastinal nodes, gastrohepatic nodes |
| Pancreatic Adenocarcinoma | Common | retroperitoneal nodes |
| Merkel Cell Carcinoma | Common | CT sensitivity for local lymph node involvement is only 20%. |
| Pancreatic Neuroendocrine | Common | |
| Papillary Thyroid Carcinoma | Common | much more common than distant metastases |
| Medullary Thyroid Carcinoma | Common | |
| Cholangiocarcinoma | Common | |
| Gallbladder Cancer | Common | |
| Neuroblastoma | Common | |
| Basal Cell Carcinoma | Common | |
| Mixed Mullerian Tumor of the Uterus | Common | |
| Olfactory Neuroblastoma | Common | Most common site of metastasis is the cervical lymph node chain. |
| Gastrointestinal Carcinoid | Common | Fibrosis (desmoplastic reaction) can cause kinking of bowel and obstruction. Often the mesenteric lymphadenopathy may be larger than the primary tumor, in the case of small intestine primaries. Around 70% of mesenteric lymph node metastases contain calcification. |
| Transitional Cell Carcinoma of the Bladder | Common | |
| Hodgkin's Lymphoma | Common | Spreads contiguously. Most commonly to hilar or cervical chain. |
| Gastrointestinal Stromal Tumor | Rare | |
| Pheochromocytoma | Common | |
| Dermatofibrosarcoma Protuberans | Rare | |