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Metastatic Pattern of Spread of Olfactory Neuroblastoma  adult

Introduction: Also known as esthesioneuroblastoma. This small round blue cell tumor involves the olfactory nerves and often presents as a mass within the nasal cavity. It may invade the paranasal sinuses or the brain through the cribriform plate.

Late metastasis is often described.

Prevalence: Very Rare Metastasis Frequency: Common

ISRN Oncol. 2011;2011:451086. doi: 10.5402/2011/451086 PMID: 22084732

AJNR Am J Neuroradiol. 2011 May;32(5):929-33. PMID: 21349970

Primary Tumor:

 Characteristics Comments
Nasal Cavity

Known Metastatic Locations:

SiteFrequencyCharacteristics Comments
Local Lymph Nodes Common Most common site of metastasis is the cervical lymph node chain.
Brain UncommonCystic The tumor may invade the frontal lobe directly. Intracranial cysts have also been described.