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Metastasis: Blastic Bone Lesion

Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site.


Prostate Adenocarcinoma Common adult most common site (90%)
Small Cell Lung Cancer Common adult
Osteosarcoma (Primary Tumor) adultchild Typically arises in the metaphysis of long bones.
Pancreatic Neuroendocrine Uncommon adult
Transitional Cell Carcinoma of the Bladder Common adult
Osteosarcoma Uncommon adultchild hematogenous metastases to the spine or pelvis are most common
Gastrointestinal Carcinoid Uncommon adult Classically, these are blastic metastases, but a recent series showed both lytic and blastic lesions (PMID: 12571207).
Medulloblastoma Common adultchild most common site of distant metastasis
Hodgkin's Lymphoma Rare adultchild Most commonly involves the spine. Involves bone usually by direct extension.