Metastasis: Hypoenhancing Spleen Lesion
Cancers are sorted by a combination of rarity, overall frequency of metastases, and predilection for this site.
| Cancer | Frequency | Comments |
| Hodgkin's Lymphoma | Common |   Most commonly radiographically occult, but can present with hypoattenuating nodules or as splenomegaly. Splenomegaly (especially mild) does not imply involvement, however. |
| Non-Hodgkin's Lymphoma | Uncommon | can be radiographically occult, manifest as enlargement of the spleen, or manifest as focal lesions |